Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Maize C. Cao, Andrew Chancellor, Alison Charleston, Mike Dragunow & Emma L. Scotter
This study recently examined the rate of MND in New Zealand using mortality (death certificate) data from Statistics Aotearoa. Previous studies have indicated that there appears to be an unusually high rate of incidence of MND in New Zealand, these studies have been on a regional level which means that this rate can not be extended to estimate the incidence for the entire country. Given this lack of information about MND incidence in New Zealand as a whole, national mortality records were sought to infer disease burden and determine whether New Zealand indeed has high or increasing rates of MND. While there are a number of potential shortcomings associated with inferring disease incidence from mortality, the findings supported previous studies that suggest a relatively high MND incidence rate in New Zealand.
It was found that that the proportion of people in NZ who die from MND is higher than any other country that was examined using identical methodology. Whereas the average rate elsewhere is 1.67 deaths from MND per 100,000 people living in the population, New Zealand’s rate is 2.3-2.8 deaths from MND per 100,000 people living in the population. To ensure the results were able to be compared they were age standardised and only compared to international results that had also been age standardised.
European countries also tend have higher MND rates. Since approximately 74% of New Zealand’s population is of Caucasian/European descent this may be due to shared ancestry and our population may share genetic and lifestyle risk factors with Europeans. Maori population data showed a lower mortality from MND compared to the total population, which could be for several reasons. Further studies may help to determine if unique genetic risk factors are present in the NZ population, and may also shed light on any occupational or environmental factors that are at play.
There is anticipation that the MND patient registry will be able to tell us more about the burden of MND in New Zealand. This registry is New Zealand population based and allows multiple source collection streams for incidence data analysis.
The full article is available here.
The high rate of MND mortality in NZ was reported on TVNZ One News during MND awareness week – the story can be viewed here.